Oncology Loses a Pioneer

Parnham—A Pioneer Venture

A parasite pioneer

The concept that infectious biological agents were responsible for many diseases was controversial in the midnineteenth century. But key experiments by famed scientists such as Louis Pasteur and Robert Koch eventually won over sceptics. However, some other researchers, equally convinced by this notion, and who also carried our convincing experiments in its support at the same time, have failed ...

HIV Pathogenesis: Nef Loses Control

In this issue of Cell, Schindler et al. (2006) show that the Nef protein from nonpathogenic strains of simian immunodeficiency virus (SIV) induces the downregulation of host T cell receptor/CD3, whereas Nef from human immunodeficiency virus (HIV-1) does not. This loss of function in the Nef of HIV-1 may partly explain the pathogenicity of this virus.

Migration: Who Gains, Who Loses

Arvind Panagariya Analytically as well as politically, migration is a more complex phenomenon than international trade. The latter involves two-way flows of goods and services that allow the real aggregate income to grow in each country involved. Therefore, the arguments for protection against imports typically rest on the detrimental effects on the income distribution or the existence of prior...

Donato D’Angelo – a pioneer☆

of his doctoral thesis presented in 1970, gives an idea to our he beginnings of orthopedics as an academic institution and pecific professional activity in Brazil dates back to approxiately 60 years ago. Before then, patients with clinical problems of the locootor apparatus were treated by surgeons or pediatricians, nd those with problems resulting from trauma by surgeons r curious individuals ...